Metformin Impairs Intestinal Fructose Metabolism
W. Tong, S. A. Hannou, A. Sargsyan…·M. A. Herman
This study shows metformin reduces intestinal fructose metabolism and glucose production, along with decreased fructose delivery to the liver in mice.
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4 papers
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W. Tong, S. A. Hannou, A. Sargsyan…·M. A. Herman
This study shows metformin reduces intestinal fructose metabolism and glucose production, along with decreased fructose delivery to the liver in mice.
W. Tong, S. A. Hannou, Y. Wang…·M. A. Herman
This study identifies the intestine as the primary source of circulating TCA cycle intermediates in mice, showing endogenous production exceeds microbial contributions.
A. Sargsyan, L. Doridot, S. A. Hannou…·M. A. Herman
The paper identifies HGFAC as a ChREBP-regulated hepatokine that improves glucose and lipid homeostasis through activation of PPARγ in mice.