W. Tong

Perturbational single-cell profiling of patient tumors defines lineage- and context-specific programs of innate immune resistance

The paper uses patient tumor samples to identify lineage- and context-specific mechanisms of innate immune resistance through perturbational single-cell RNA sequencing.

Marine biofilms: cyanobacteria factories for the global oceans

This study reveals marine biofilms as a major habitat for cyanobacteria, showing distinct diversity and functional adaptations compared to seawater, with diversification linked to key geological events.

Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds

This paper introduces a battery-free optoelectronic patch for photodynamic and light therapies to treat bacterial infections, showing reduced bacterial load and enhanced tissue regeneration in animal models.

DICTrank: The largest reference list of 1318 human drugs ranked by risk of drug-induced cardiotoxicity using FDA labeling

The paper develops DICTrank, a comprehensive list of 1318 human drugs ranked by cardiotoxicity risk using FDA labeling, identifying therapeutic categories with high DICT potential.

Metformin Impairs Intestinal Fructose Metabolism

This study shows metformin reduces intestinal fructose metabolism and glucose production, along with decreased fructose delivery to the liver in mice.

Evolution of horn length and lifting strength in the Japanese rhinoceros beetle Trypoxylus dichotomus

The paper studies the evolution of horn length and lifting strength in Trypoxylus dichotomus, showing independent increases in horn length in Northern and Southern lineages with mechanical trade-offs and compensatory changes.

PTHrP buffers Wnt/Beta-catenin activity through a negative feedback loop to maintain articular cartilage homeostasis

This study identifies a Wnt/β-catenin-PTHrP negative feedback loop that maintains articular cartilage homeostasis and prevents osteoarthritis progression.

Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone

Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis

This study identifies Kindlin-2 as a protective factor in articular cartilage, showing its role in preventing osteoarthritis through regulation of Stat3 and Runx2 pathways.

Aucubin promoted neuron functional recovery by suppressing inflammation and neuronal apoptosis in a spinal cord injury model

This study shows that aucubin promotes functional recovery after spinal cord injury by reducing inflammation and neuronal apoptosis through the TLR4/NF-κB pathway and mitochondrial protection.

The Intestine is a Major Contributor to Circulating TCA Cycle Intermediates in Mice

This study identifies the intestine as the primary source of circulating TCA cycle intermediates in mice, showing endogenous production exceeds microbial contributions.

HGFAC is a ChREBP Regulated Hepatokine that Enhances Glucose and Lipid Homeostasis

The paper identifies HGFAC as a ChREBP-regulated hepatokine that improves glucose and lipid homeostasis through activation of PPARγ in mice.

Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samples

This study identifies FFPE processing errors in oncology panel sequencing by analyzing variants from technical artifacts in FFPE samples with varying fixation times and block positions.

Inhibition of ITK differentiates GVT and GVHD in allo-HSCT

This paper shows that inhibiting ITK in donor T cells reduces GVHD while preserving GVT effects in allo-HSCT using murine models and a novel peptide inhibitor.

Single cell transcriptomics identifies a unique adipocyte population that regulates bone marrow environment

The paper identifies a unique adipocyte population in bone marrow, MERAs, that regulate bone and vessel homeostasis through single-cell transcriptomics in mice.

Behavioural mechanisms underlying the evolution of cooperative burrowing in Peromyscus mice

The paper investigates how Peromyscus mice adapt their burrowing behavior when digging individually versus with partners, finding that cooperative digging results in longer burrows due to increased social cohesion in opposite-sex pairs.

Muscle-secreted G-CSF as a metabolic niche factor ameliorates loss of muscle stem cell in aged mice

This study identifies G-CSF as a metabolic niche factor that replenishes Pax7Hi muscle stem cells in aged mice through exercise-induced mechanisms.