Author

P. A. Murphy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. L. Kimble· 3 shared E. R. Jellison· 3 shared J. A. Hensel· 3 shared B. Reese· 2 shared S.-A. E. Nicholas· 2 shared A. Dong· 1 shared A. Menoret· 1 shared A. Rodriguez-Oquendo· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCell Biology

A. L. Kimble

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The Implant-Induced Foreign Body Response is Limited by CD13-Dependent Regulation of Ubiquitination of Fusogenic Proteins

M. Ghosh, F. McGurk, R. Norris, A. Dong, S. Nair, E. Jellison, P. A. Murphy, R. Verma, L. H. Shapiro

This study shows CD13 regulates macrophage fusion by controlling ubiquitination of fusogenic proteins, limiting foreign body response fibrosis and suggesting CD13 as a therapeutic target.

The Journal of Immunology · Dec 27, 2023Peer-reviewedCell Biology

Splice Factor Polypyrimidine tract-binding protein 1 (Ptbp1) is Required for Immune Priming of the Endothelium in Atherogenic Disturbed Flow Conditions

J. A. Hensel, S.-A. E. Nicholas, E. R. Jellison, A. L. Kimble, A. Menoret, M. Ozawa, A. Rodriguez-Oquendo, A. T. Vella, P. A. Murphy

This study identifies Ptbp1 as a critical splice factor required for endothelial priming in atherogenic disturbed flow conditions, linking its regulation of splicing and NFκB activation to vascular inflammation.

bioRxiv · Jun 18, 2021 · PreprintCell Biology

A Method for Rapid Flow-cytometric Isolation of Endothelial Nuclei and RNA from Archived Frozen Brain Tissue

A. L. Kimble, J. Silva, M. Murphy, J. A. Hensel, S.-A. E. Nicholas, E. R. Jellison, B. Reese, P. A. Murphy

This paper develops a method to isolate endothelial nuclei and RNA from archived frozen brain tissues, showing it reliably extracts endothelial RNA and correlates with whole-cell expression.

bioRxiv · May 12, 2021Cell Biology

Identification of Splice Regulators of Fibronectin-EIIIA and EIIIB by Direct Measurement of Exon Usage in a Flow-Cytometry Based CRISPR Screen

J. A. Hensel, B. D. Heineman, A. L. Kimble, E. R. Jellison, B. Reese, P. A. Murphy

The paper develops a flow-cytometry based CRISPR screen to identify splice regulators of fibronectin-EIIIA and EIIIB exons, identifying known and novel regulators and implicating TNFalpha and RIG-I-like signaling pathways.

bioRxiv · May 5, 2021Cell Biology