Early consequences of the phospholamban mutation PLN-R14del+/- in a transgenic mouse model
C. Maniezzi, M. Eskandr, C. Florindi, M. Ferrandi, P. Barassi, E. Sacco, V. Pasquale, A. S. Maione, G. Pompilio, V. Oliveira Nunes Teixeira, R. A. de Boer, H. H. W. Sillje, F. Lodola, A. Zaza
This study examines Ca2+ dynamics and energy metabolism in a transgenic mouse model of the PLN-R14del mutation before cardiomyopathy onset, finding altered mitochondrial function and ER-stress activation.
bioRxiv · Apr 5, 2023Physiology