Author

P. Cejka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 4 Organism:human· 4 Organism:yeast· 3 Research Focus:cell signaling & trafficking· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

R. Seidel· 3 shared A. Acharya· 2 shared E. Cannavo· 2 shared H. Bret· 2 shared K. Kasaciunaite· 2 shared R. Anand· 2 shared R. Guerois· 2 shared V. Borde· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

R. Seidel

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Comprehensive Interrogation of Synthetic Relationships in the Human DNA Damage Response

J. Fielden, S. M. Siegner, D. N. Gallagher, M. Schroeder, M. R. Dello Stritto, L. Kobel, M. Schlapansky, P. Cejka, M. Jost, J. E. Corn

The paper maps genetic interactions of DDR genes using CRISPRi screening, identifies key interactions with therapeutic potential, and provides insights into genome maintenance mechanisms.

bioRxiv · Aug 18, 2023Cell Biology

Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP

Y. Nicolas, H. Bret, E. Cannavo, P. Cejka, V. Borde, R. Guerois

This study reveals how Sae2/CtIP activates Mre11 nuclease activity through structural and biochemical analyses in yeast and human systems.

bioRxiv · Aug 5, 2023Biochemistry

Mechanism of DNA unwinding by hexameric MCM8-9 in complex with HROB

A. Acharya, H. Bret, J.-W. Huang, M. Muetze, M. Goese, V. Kissling, R. Seidel, A. Ciccia, R. Guerois, P. Cejka

This study investigates how HROB regulates the DNA unwinding activity of the MCM8-9 helicase complex through structural and biochemical analyses.

bioRxiv · Jun 12, 2023 · PreprintBiochemistry

Regulation of the MLH1-MLH3 endonuclease in meiosis

E. Cannavo, A. Sanchez, R. Anand, L. Ranjha, J. Hugener, C. Adam, A. Acharya, N. Weyland, X. Aran-Guiu, J.-B. Charbonnier, E. R. Hoffman, V. Borde, J. Matos, P. Cejka

This paper identifies the molecular mechanism by which the MLH1-MLH3 nuclease is activated in meiosis, showing its interaction with MutSγ, EXO1, RFC, and PCNA to process recombination intermediates.

bioRxiv · Feb 12, 2020Biochemistry

CtIP promotes the motor activity of DNA2 to accelerate long-range DNA end resection

I. Ceppi, S. M. Howard, K. Kasaciunaite, C. Pinto, R. Anand, R. Seidel, P. Cejka

This study shows phosphorylated CtIP enhances DNA2's motor activity, promoting RPA-coated ssDNA degradation and linking short and long-range DNA resection.

bioRxiv · Oct 1, 2019Biochemistry

Competing interactions modulate the activity of Sgs1 during DNA end resection

K. Kasaciunaite, F. Fettes, M. Levikova, P. Daldrop, P. Cejka, R. Seidel

This study investigates how Sgs1's activity is modulated by competing interactions with Dna2, RPA, and Top3-Rmi1 during DNA end resection in yeast.

bioRxiv · Jan 9, 2019 · PreprintBiochemistry