BiochemistrybioRxiv
CtIP promotes the motor activity of DNA2 to accelerate long-range DNA end resection
I. Ceppi, S. M. Howard, K. Kasaciunaite…·P. Cejka
This study shows phosphorylated CtIP enhances DNA2's motor activity, promoting RPA-coated ssDNA degradation and linking short and long-range DNA resection.
DOI 10.1073/pnas.2001165117