Altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa define colitis associated with immune checkpoint inhibitors
M. Thomas, K. Slowikowski, K. Manakongtreecheep, P. Sen, J. Tantivit, M. Nasrallah, N. Smith, S. Ramesh, L. Zubiri, A. Tirard, B. Arnold, L. Nieman, J. Chen, T. Eisenhaure, K. Pelka, , A.-C. Villani
This study identifies altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa in immune checkpoint inhibitor-associated colitis using single-cell RNA sequencing and other multi-omics approaches.
bioRxiv · Sep 17, 2021Immunology