Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function
K. A. Helmin, L. Morales-Nebreda, M. A. Torres Acosta, K. R. Anekalla, S.-Y. Chen, H. Abdala-Valencia, Y. Politanska, P. Cheresh, M. Akbarpour, E. M. Steinert, S. E. Weinberg, B. D. Singer
This study shows that maintenance DNA methylation, regulated by Uhrf1, is essential for Treg cell development and stability of their suppressive function.
bioRxiv · Feb 3, 2020Immunology