Damage-induced pyroptosis drives endogenous thymic regeneration viainduction of Foxn1 by purinergic receptor activation
S. Kinsella, C. A. Evandy, K. Cooper, A. Cardinale, L. Iovino, P. deRoos, K. S. Hopwo, C. W. Smith, D. W. Granadier, L. B. Sullivan, E. Velardi, J. Dudakov
The paper identifies that damage-induced pyroptosis of thymocytes, mediated by purinergic receptor activation and Foxn1 upregulation, drives thymic regeneration after acute injury.
bioRxiv · Jan 19, 2023 · PreprintImmunology