Age-related epithelial defects limit thymic function and regeneration
A. I. Kousa, L. Jahn, K. Zhao, A. E. Flores, D. Granadier, K. Cooper, J. M. Sheridan, A. Lemarquis, L. Sikkema, K. V. Argyropoulos, J. Tsai, A. Lazrak, K. Nichols, N. Lee, R. Ghale, , M. R. van den Brink
The paper identifies age-related thymic epithelial cell states that impair thymic regeneration and immune function through spatial and single-cell transcriptomics.
bioRxiv · Dec 16, 2021Immunology