Activation of goblet cell stress sensor IRE1β is controlled by the mucin chaperone AGR2
E. Cloots, P. Guilbert, M. Provost, L. Neidhardt, E. Van de Velde, F. Fayazpour, D. De Sutter, S. N. Savvides, S. Eyckerman, S. Janssens
This study identifies AGR2 as a chaperone that regulates IRE1β activity in goblet cells by preventing its dimerization and endonuclease activity.
bioRxiv · Jul 6, 2023Cell Biology