Cell BiologybioRxiv
Activation of goblet cell stress sensor IRE1β is controlled by the mucin chaperone AGR2
E. Cloots, P. Guilbert, M. Provost…·S. Janssens
This study identifies AGR2 as a chaperone that regulates IRE1β activity in goblet cells by preventing its dimerization and endonuclease activity.
DOI 10.1038/s44318-023-00015-y