Author

E. Cloots

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

D. De Sutter· 2 shared S. Eyckerman· 2 shared S. Janssens· 2 shared A. W. Paton· 1 shared E. Van de Velde· 1 shared F. Fayazpour· 1 shared H. De Luca· 1 shared J. C. Paton· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

D. De Sutter

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2 papers

Recent·Most cited

Activation of goblet cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

E. Cloots, P. Guilbert, M. Provost, L. Neidhardt, E. Van de Velde, F. Fayazpour, D. De Sutter, S. N. Savvides, S. Eyckerman, S. Janssens

This study identifies AGR2 as a chaperone that regulates IRE1β activity in goblet cells by preventing its dimerization and endonuclease activity.

bioRxiv · Jul 6, 2023Cell Biology

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

M. J. Grey, E. Cloots, M. S. Simpson, N. LeDuc, Y. Serebrenik, H. De Luca, D. De Sutter, P. Luong, J. R. Thiagarajah, A. W. Paton, J. C. Paton, M. Seeliger, S. Eyckerman, S. Janssens, W. I. Lencer

This study shows IRE1β suppresses IRE1α signaling during ER stress by blocking its activation and disrupting a feedback loop that regulates IRE1 expression.

bioRxiv · Mar 23, 2019Cell Biology