Citrullination of glucokinase linked to autoimmune diabetes
M.-L. Yang, S. Horstman, R. Gee, P. Guyer, T. Lam, J. Kanyo, A. Perdigoto, C. Speake, C. J. Greenbaum, L. Overbergh, R. Kibbey, K. C. Herold, E. A. James, M. J. Mamula
This study identifies citrullination of glucokinase as an inflammatory-driven PTM that triggers autoimmunity and impairs glucose metabolism in Type 1 diabetes.
bioRxiv · Apr 28, 2021Immunology