T. Lam

CD388: A universally protective Drug-Fc Conjugate that targets influenza virus neuraminidase

This paper describes CD388, a drug-Fc conjugate that targets influenza virus neuraminidase, showing universal antiviral activity across multiple strains and demonstrating efficacy in mouse models.

The hyperphosphorylation of SARS-CoV-2s nucleocapsid protein by GSK-3 involves a complex and redundant priming mechanism

This study reveals that SARS-CoV-2 nucleocapsid protein hyperphosphorylation by GSK-3 involves a complex, cooperative priming mechanism rather than simple sequential phosphorylation.

Proteolytic Cleavage of the ENaC gamma Subunit: Impact Upon Na+ and K+ Handling

This study investigates the impact of proteolytic cleavage of the ENaC gamma subunit on Na+ and K+ handling in mice, finding that cleavage is not essential for channel activity in vivo.

Congenital T cell activation impairs transitional to follicular B cell maturation in humans

Congenital T cell activation in CTLA4-deficient patients impairs transitional to follicular B cell maturation and can be rescued by CTLA4 replacement therapy in vivo.

A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell-cell contacts

The paper identifies a complex of TMEM24 and C2CD2 with band 4.1 proteins at ER/PM junctions, showing their role in lipid transport and cell-cell contact regulation.

Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis

The paper identifies dual regulation of SLC25A39 by AFG3L2 and iron, showing how this controls mitochondrial glutathione homeostasis in neurons.

Evolutionary fingerprints of EMT in pancreatic cancers

This study investigates the role of EMT in pancreatic cancer evolution and metastasis, showing that mesenchymal lineages drive chromosomal instability and clonal evolution.

Mechanosensing through talin 1 contributes to tissue mechanical homeostasis

This study shows that mutations in talin1 alter cellular stiffness sensing, leading to changes in ECM mechanical properties and aortic compliance.

Influence of MUC1 on trafficking of TRPV5 and TRPV6 and in vivo Ca2+ homeostasis.

This study investigates how MUC1 affects TRPV5 and TRPV6 trafficking and Ca2+ homeostasis, finding that MUC1 reduces endocytosis of these channels and influences blood Ca2+ levels in mice and humans.

Carbonyl Post-Translational Modification Associated with Early Onset Type 1 Diabetes Autoimmunity

The paper identifies carbonylated P4Hb as an autoantigen in type 1 diabetes, detected before hyperglycemia in NOD mice and early human disease.

Citrullination of glucokinase linked to autoimmune diabetes

This study identifies citrullination of glucokinase as an inflammatory-driven PTM that triggers autoimmunity and impairs glucose metabolism in Type 1 diabetes.

Water and Electrolyte Homeostasis in a Mouse Model with Reduced ENaC Gamma Subunit Expression

This study examines the role of the ENaC gamma subunit in electrolyte and fluid homeostasis using a mouse model with reduced gamma subunit expression, finding altered responses to dietary changes and fluid balance.

Type IV competence pili in Streptococcus pneumoniae are highly dynamic structures that retract to promote DNA uptake

This study shows that type IV competence pili in Streptococcus pneumoniae dynamically extend and retract, with retraction essential for DNA uptake during natural transformation.