Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
C. E. Gustafson, Z. Thomson, Z. He, E. Swanson, K. Henderson, M.-P. L. Pebworth, L. Y. Okada, A. T. Heubeck, C. R. Roll, V. Hernandez, M. D. Weiss, P. C. Genge, J. Reading, J. R. Giles, S. Manne, , P. J. Skene
The study identifies age-related differences in naive T cell compartments between children and adults, showing distinct molecular reprogramming in CD4 and CD8 subsets.
bioRxiv · Oct 4, 2022 · PreprintImmunology
A. J. Greaney, R. T. Eguia, T. N. Starr, K. Khan, N. Franko, J. K. Logue, S. M. Lord, C. Speake, H. Y. Chu, A. Sigal, J. D. Bloom
The paper examines the antibody response to the SARS-CoV-2 Delta variant, showing it targets class 1 and 2 epitopes more than class 3, and that mutations in these regions reduce antibody binding.
bioRxiv · Mar 12, 2022Microbiology
M. Smithmyer, A. E. Wiedeman, D. A. G. Skibinski, A. K. Savage, C. Acosta-Vega, S. Scheiding, V. H. Gersuk, S. A. Long, J. H. Buckner, C. Speake
The paper detects sample annotation errors in cytometry data by comparing HLA allele expression with longitudinal and qPCR data, identifying mismatches in 2.4% of samples.
bioRxiv · Oct 26, 2021Immunology
K. Lambert, K. G. Moo, A. Arnett, G. Goel, K. J. Flynn, C. Speake, A. E. Wiedeman, C. J. Greenbaum, S. A. Long, R. Partridge, J. H. Buckner, B. Khor
The paper uses permutational analysis to reveal advanced immune aging in Down syndrome and type 1 diabetes.
bioRxiv · Sep 13, 2021 · PreprintImmunology
M.-L. Yang, S. Connolly, R. Gee, T. Lam, J. Kanyo, S. G. Clarke, C. F. Clarke, E. A. James, C. Speake, C. Evans-Molina, L. Wen, K. C. Herold, M. Mamula
The paper identifies carbonylated P4Hb as an autoantigen in type 1 diabetes, detected before hyperglycemia in NOD mice and early human disease.
bioRxiv · Jun 15, 2021 · PreprintImmunology
M.-L. Yang, S. Horstman, R. Gee, P. Guyer, T. Lam, J. Kanyo, A. Perdigoto, C. Speake, C. J. Greenbaum, L. Overbergh, R. Kibbey, K. C. Herold, E. A. James, M. J. Mamula
This study identifies citrullination of glucokinase as an inflammatory-driven PTM that triggers autoimmunity and impairs glucose metabolism in Type 1 diabetes.
bioRxiv · Apr 28, 2021Immunology
F. W. Soveg, J. Schwerk, N. S. Gokhale, K. Cerosaletti, J. R. Smith, E. Pairo-Castineira, A. M. Kell, A. Forero, S. A. Zaver, K. Esser-Nobis, J. Roby, T.-Y. Hsiang, S. Ozarkar, J. M. Clingan, E. T. McAnarney, , R. Savan
This study shows that the OAS1 p46 isoform, targeted to the endomembrane system, enhances antiviral activity against RNA viruses and is associated with COVID-19 severity.
bioRxiv · Apr 21, 2021Immunology
H. Bolouri, C. Speake, D. Skibinski, S. A. Long, A. M. Hocking, D. J. Campbell, J. A. Hamerman, U. Malhotra, J. H. Buckner, BRI COVID-19 Research Team
This study identifies three immune clusters in COVID-19 patients correlated with disease severity and shows that immune responses change dynamically with clinical outcomes.
bioRxiv · Sep 18, 2020Immunology
E. K. Sims, J. Nyalwidhe, F. Syed, H. T. Bahnson, L. Haataja, C. Speake, M. Morris, R. G. Mirmira, J. Nadler, T. L. Mastracci, P. Arvan, C. J. Greenbaum, C. Evans-Molina
The paper investigates proinsulin processing abnormalities in T1D islets, finding reduced processing enzymes and cytokine-induced expression changes.
bioRxiv · Feb 8, 2019Pathology