Carbonyl Post-Translational Modification Associated with Early Onset Type 1 Diabetes Autoimmunity
M.-L. Yang, S. Connolly, R. Gee, T. Lam, J. Kanyo, S. G. Clarke, C. F. Clarke, E. A. James, C. Speake, C. Evans-Molina, L. Wen, K. C. Herold, M. Mamula
The paper identifies carbonylated P4Hb as an autoantigen in type 1 diabetes, detected before hyperglycemia in NOD mice and early human disease.
bioRxiv · Jun 15, 2021 · PreprintImmunology