ImmunologybioRxiv
Pre-T cell receptor Self-MHC Sampling Restricts Thymocyte Dedifferentiation
J. S. Duke-Cohan, A. Akitsu, R. J. Mallis…·E. L. Reinherz
The paper shows that preTCR-pMHC interactions prevent thymocyte dedifferentiation by analyzing single-cell transcriptomes in fetal thymic cultures with and without pMHC.
DOI 10.1038/s41586-022-05555-7