Parsing digital or analogue TCR performance through piconewton forces
A. Akitsu, E. Kobayashi, Y. Feng…·E. Reinherz
The paper examines how TCR performance differs under physical force, finding digital TCRs are more effective in vivo.
Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
A. Akitsu, E. Kobayashi, Y. Feng…·E. Reinherz
The paper examines how TCR performance differs under physical force, finding digital TCRs are more effective in vivo.
A. C. Chang-Gonzalez, R. J. Mallis, M. J. Lang…·W. Hwang
The paper uses molecular dynamics simulations to show how asymmetric motion of TCR alpha beta chains affects peptide discrimination under mechanical force.
J. S. Duke-Cohan, A. Akitsu, R. J. Mallis…·E. L. Reinherz
The paper shows that preTCR-pMHC interactions prevent thymocyte dedifferentiation by analyzing single-cell transcriptomes in fetal thymic cultures with and without pMHC.