BiochemistrybioRxiv
Bio-Orthogonal Chemistry Enables Solid Phase Synthesis of Long RNA Oligonucleotides
M. He, P. Haruehanroengra, I. Khan…·M. Royzen
This paper develops a bio-orthogonal chemistry method for synthesizing long RNA oligonucleotides, achieving 76-nt tRNA and 101-nt sgRNA with high purity and functional fidelity.
DOI 10.1039/d1cc00096a