BiochemistrybioRxiv
A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance
F. van der Krift, D. W. Zijlmans, R. Shukla…·M. M. Maurice
This study identifies a novel antifolate, C1, that overcomes methotrexate resistance by targeting FPGS-deficient cells through DHFR inhibition.
DOI 10.26508/lsa.202302058