BiochemistrybioRxiv
Mechano-redox control of Mac-1 de-adhesion from ICAM-1 by protein disulfide isomerase promotes directional movement of neutrophils under flow
A. Dupuy, C. Aponte Santamaria, A. Yeheskel…·J. Chiu
This study identifies PDI-mediated cleavage of a disulfide bond in Mac-1 as a mechanism enabling neutrophil directional movement under flow by promoting de-adhesion from ICAM-1.
DOI 10.1161/circresaha.122.321926