ImmunologybioRxivPreprint
MicroRNA-221/222-expression in HSC and MPP safeguards their quiescence and multipotency by downregulating stress-independent and dependent expression of IEG and of several myelo/granulopoiesis-enhancing target genes.
P. K. Jani, G. Petkau, Y. Kawano…·F. Melchers
This study shows that miR-221/222 in HSC and MPP maintains quiescence and multipotency by suppressing IEGs and myelo/granulopoiesis genes, with implications for improving bone marrow transplants.
DOI 10.1101/2023.01.30.526397