Author

F. Heinrich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biophysics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Research Focus:differential expression· 3 Organism:human· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Approach:deep learning· 2

Frequent Co-Authors

M.-F. Mashreghi· 4 shared P. Durek· 4 shared G. A. Heinz· 3 shared K. Lehmann· 3 shared A. Radbruch· 2 shared G. M. Guerra· 2 shared H.-D. Chang· 2 shared M. Loesche· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersImmunology

M.-F. Mashreghi

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Single cell analysis reveals CD45RClow/-TNFR2+CD29lowCD8+ Tregs with superior activity

C. Serazin, L. Flippe, M. Streitz, D.-J. Wendering, S. Schlickeiser, F. Heinrich, P. Durek, G. M. Guerra, K. Lehmann, M.-F. Mashreghi, H. Wajant, H.-D. Volk, I. Anegon, L. David, S. Bezie, C. Guillonneau

The paper identifies and characterizes three subsets of human CD8+ regulatory T cells using single-cell CITE-seq and VDJ sequencing, highlighting a subset with superior suppressive activity.

bioRxiv · Dec 13, 2023 · PreprintImmunology

MicroRNA-221/222-expression in HSC and MPP safeguards their quiescence and multipotency by downregulating stress-independent and dependent expression of IEG and of several myelo/granulopoiesis-enhancing target genes.

P. K. Jani, G. Petkau, Y. Kawano, U. Klemm, G. M. Guerra, G. A. Heinz, F. Heinrich, P. Durek, M.-F. Mashreghi, F. Melchers

This study shows that miR-221/222 in HSC and MPP maintains quiescence and multipotency by suppressing IEGs and myelo/granulopoiesis genes, with implications for improving bone marrow transplants.

bioRxiv · Jan 30, 2023 · PreprintImmunology

SARS-CoV-2 infects carotid arteries: implications for vascular disease and organ injury in COVID-19

S. Pfefferle, T. Guenther, V. Puelles, F. Heinrich, D. Noerz, M. Czech-Sioli, A. Carstens, S. Krasemann, M. Wong, L. Oestereich, T. Magnus, L. Allweiss, C. Edler, A.-S. Schroeder, M. Dandri, , N. Fischer

The paper investigates SARS-CoV-2 infection in carotid arteries of COVID-19 patients using genomic, virologic, histochemical, and transcriptomic analyses, showing productive infection and vascular modulation.

bioRxiv · Oct 10, 2020 · PreprintMicrobiology

Antigen-driven PD1+Tox+Eomes+ and PD1+Tox+BHLHE40+ synovial T lymphocytes regulate chronic inflammation in situ

P. Maschmeyer, G. A. Heinz, C. Skopnik, L. Lutter, A. Mazzoni, F. Heinrich, S. L. von Stuckrad, L. E. Wirth, C. L. Tran, R. Riedel, K. Lehmann, I. Sakwa, R. Cimaz, F. Giudici, M. A. Mall, , M.-F. Mashreghi

The paper identifies distinct subpopulations of synovial T lymphocytes in JIA patients using single-cell RNA-sequencing and shows their roles in regulating chronic inflammation.

bioRxiv · Dec 27, 2019 · PreprintImmunology

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

R. Riedel, R. K. Addo, M. Ferreira-Gomes, G. A. Heinz, F. Heinrich, J. Kummer, V. Greiff, D. Schulz, C. Klaeden, R. Cornelis, U. Menzel, S. Kröger, U. Stervbo, R. Köhler, C. Haftmann, , A. Radbruch

The paper identifies discrete populations of isotype-switched memory B cells in murine spleen and bone marrow, with distinct locations and characteristics.

bioRxiv · Oct 31, 2019Immunology

Steering Molecular Dynamics Simulations of Membrane-Associated Proteins with Neutron Reflection Results

B. W. Treece, F. Heinrich, A. Ramanathan, M. Loesche

The paper introduces a method to integrate neutron reflectometry data into molecular dynamics simulations to improve structural accuracy and conformational exploration of membrane-associated proteins.

bioRxiv · Oct 30, 2019Biophysics

Association of Model Neurotransmitters with Lipid Bilayer Membranes

M. Loesche, F. Heinrich, B. Josey, V. Silin

This study quantifies neurotransmitter interactions with lipid bilayers using surface plasmon resonance and neutron reflectometry, showing serotonin binds non-specifically while GABA does not.

bioRxiv · Oct 29, 2019Biophysics