Pharmacology & ToxicologybioRxiv
Proteolysis Targeting Chimeras With Reduced Off-targets
T. M. Nguyen, V. Sreekanth, A. Deb…·A. Choudhary
This study develops a platform to identify off-target degradation of ZF proteins by PROTACs and identifies design rules to reduce off-target effects using pomalidomide analogs.
DOI 10.1038/s41557-023-01379-8