Shigella O-specific polysaccharide functional IgA responses mediate protection against shigella infection in an endemic high-burden setting
B. Bernshtein, M. Kelly, D. Cizmeci, J. A. Zhiteneva, R. Macvicar, M. Kamruzzaman, T. R. Bhuiyan, F. Chowdhury, A. I. Khan, F. Qadri, R. C. Charles, P. Xu, P. Kovac, R. W. Kaminski, G. Alter, E. T. Ryan
This study identifies OSP-specific functional IgA responses as protective against shigella infection in high-burden settings by enhancing neutrophil and monocyte activation.
bioRxiv · May 4, 2023Immunology