R. Biswas

Atomically accurate de novo design of antibodies with RFdiffusion

This paper designs antibodies de novo with atomic precision using RFdiffusion and yeast display, validated by cryo-EM and biophysical methods.

Rapid resistance profiling of SARS-CoV-2 protease inhibitors

The paper compares resistance profiles of nirmatrelvir, ensitrelvir, and FB2001 against SARS-CoV-2 Mpro variants using a cell-based assay, revealing distinct resistance mechanisms.

Neural epidermal growth factor-like 1 protein variant increases survival and modulates the inflammatory and immune responses in human ACE-2 transgenic mice infected with SARS-CoV-2

This study tests a recombinant NELL1 protein variant in a SARS-CoV-2 mouse model, showing improved survival and modulated immune responses.

Suppression of miR-155 attenuates lung cytokine storm induced by SARS-CoV-2 infection in human ACE2-transgenic mice

This study shows that suppressing miR-155 reduces lung inflammation and improves survival in SARS-CoV-2-infected human ACE2-transgenic mice.

Humans surviving cholera develop antibodies against Vibrio cholerae O-specific polysaccharide that inhibit pathogen motility

This study shows that antibodies against Vibrio cholerae O-specific polysaccharide inhibit bacterial motility and provide protection against cholera in a murine model.

Antibacterial efficacy of Jackfruit rag extract against clinically important pathogens and validation of its antimicrobial activity in Shigella dysenteriae infected Drosophila melanogaster infection model

Mechanical Instability of Adherens Junctions Overrides Intrinsic Quiescence of Hair Follicle Stem Cells

This study shows that vinculin loss in murine skin disrupts adherens junctions, leading to loss of bulge stem cell quiescence through impaired force generation and YAP1 retention.

Oral immunization with a probiotic cholera vaccine induces broad protective immunity against Vibrio cholerae colonization and disease in mice

This study shows that the live-attenuated cholera vaccine HaitiV provides protection against V. cholerae in mice and their offspring through immunological mechanisms, not vaccine transmission.

Quantitative mass spectrometry to interrogate proteomic heterogeneity in metastatic lung adenocarcinoma and validate a novel somatic mutation CDK12-G879V

The paper uses quantitative mass spectrometry to analyze proteomic and phosphoproteomic changes in metastatic lung adenocarcinoma and validates a novel somatic mutation CDK12-G879V associated with chemotherapy sensitivity.

Integrated proteogenomic analysis of metastatic thoracic tumors identifies APOBEC mutagenesis and copy number alterations as drivers of proteogenomic tumor evolution and heterogeneity