M. Kelly

Machine Learning Approaches in Label-Free Small Extracellular Vesicles Analysis with Surface-Enhanced Raman Scattering (SERS) for Cancer Diagnostics

This paper demonstrates a proof-of-concept model using machine learning and SERS to predict cancer from small extracellular vesicles, with explainable AI for interpretability.

Glioblastoma cells use an integrin- and CD44-mediated motor-clutch mode of migration in brain tissue

This study identifies a motor-clutch mechanism for glioblastoma cell migration in brain tissue, highlighting the roles of integrins, CD44, and myosin motors.

Metabolic capabilities are highly conserved among human nasal-associated Corynebacterium species in pangenomic analyses

The paper analyzes the metabolic capabilities of four common human nasal Corynebacterium species using pangenomic data, finding high conservation of core metabolic functions across species and geographic strains.

Shigella O-specific polysaccharide functional IgA responses mediate protection against shigella infection in an endemic high-burden setting

This study identifies OSP-specific functional IgA responses as protective against shigella infection in high-burden settings by enhancing neutrophil and monocyte activation.

mTOR Inhibition Suppresses Salinomycin-Induced Ferroptosis in Breast Cancer Stem Cells by Ironing Out Mitochondrial Dysfunctions

The paper shows that mTOR inhibition reduces Salinomycin-induced ferroptosis in breast cancer stem cells by modulating iron flux and mitochondrial function.

c-Src-dependent phosphorylation of Mfn2 regulates endoplasmic reticulum-mitochondria tethering

The paper shows that c-Src-dependent phosphorylation of Mfn2 reduces ER-mitochondria distance and enhances Ca2+ transfer, affecting ROS and mitochondrial bioenergetics.

Yersinia pestis genomes reveal plague in Britain 4,000 years ago

The paper identifies Yersinia pestis genomes from 4,000-year-old British remains, showing plague in Britain earlier than previously documented.

Multiplexed identification of RAS paralog imbalance as a driver of lung cancer growth

This study identifies HRAS and NRAS as suppressors of KRASG12D-driven lung cancer using CRISPR screens in mouse models and confirms their role in human cell lines.

Microbiome diversity and host immune functions may define the fate of sponge holobionts under future ocean conditions

This study examines how environmental stress affects sponge holobionts by comparing microbiome diversity and immune responses in two sponge species under acidification and warming.

CRISPR-enhanced human adipocyte 'browning' as cell therapy for metabolic disease

This paper uses CRISPR to enhance browning of human adipocytes, improving metabolic health in mice without immunogenic Cas9 exposure.

Humans surviving cholera develop antibodies against Vibrio cholerae O-specific polysaccharide that inhibit pathogen motility

This study shows that antibodies against Vibrio cholerae O-specific polysaccharide inhibit bacterial motility and provide protection against cholera in a murine model.

Single-cell atlas of tumor clonal evolution in liver cancer

This study constructs a single-cell atlas of liver cancer tumor clonality using machine learning and identifies osteopontin as a key driver of tumor evolution and immune reprogramming.

Single Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis

This study shows that adipocyte signals can drive iWAT browning through macrophage-like cells, independent of sympathetic nerves.

Spatial Capture-Recapture for Categorically Marked Populations with An Application to Genetic Capture-Recapture

The paper introduces a categorical spatial partial identity model (SPIM) to improve density estimation in populations with uncertain individual identity, showing it performs better than existing methods in high uncertainty scenarios.

Resistance to Diet Induced Obesity in the Apolipoprotein E Deficient Mouse is Associated with an Attenuated Transcriptional Response in Visceral Fat

This study shows that apoE-deficient mice have a reduced transcriptional response in visceral fat to high-fat diet, linked to increased metabolic efficiency and resistance to obesity.

CRISPR delivery particles for developing therapeutic strategies in metabolic disease

This study develops CRISPR delivery particles (CriPs) for efficient gene editing in cultured cells and in vivo, demonstrating their potential for therapeutic applications in metabolic disease.

Neuronal Modulation of Brown Adipose Activity Through Perturbation of White Adipocyte Lipogenesis

This study shows that white adipocyte lipogenesis influences brown adipose thermogenesis through neuronal signaling.

Spatial capture-recapture with partial identity: an application to camera traps

The paper introduces SPIM, a method to improve density analysis by incorporating partial identity individuals from camera traps, showing improved inference in ocelot and bobcat datasets.