E. T. Ryan

Diversity of Vibrio cholerae O1 through the human gastrointestinal tract during cholera

This study compares genetic diversity of Vibrio cholerae O1 in vomit and stool from cholera patients, finding reduced diversity in stool and some gene loss between samples.

Shigella O-specific polysaccharide functional IgA responses mediate protection against shigella infection in an endemic high-burden setting

This study identifies OSP-specific functional IgA responses as protective against shigella infection in high-burden settings by enhancing neutrophil and monocyte activation.

Use of a MAIT activating ligand, 5-OP-RU, as a mucosal adjuvant in a murine model of Vibrio cholerae O1 vaccination.

This study tests 5-OP-RU as a mucosal adjuvant in a murine cholera vaccine model, showing increased MAIT cell expansion but limited antibody response improvements.

Gut bacteria-derived sphingolipids alter innate immune responses to oral cholera vaccine antigens

This study links gut bacteria-derived sphingolipids to enhanced innate immune responses to an oral cholera vaccine using metagenomic and experimental approaches.

A combination of metagenomic and cultivation approaches reveals hypermutator phenotypes within Vibrio cholerae infected patients

The paper combines metagenomics and cultivation approaches to show V. cholerae hypermutator phenotypes in infected patients, with evidence of adaptive mutations and transversion mutations.

Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates

This paper evaluates an AAV-based COVID-19 vaccine in mice and non-human primates, showing sustained neutralizing antibodies and memory T-cells, with room-temperature stability and scalable production.

Humans surviving cholera develop antibodies against Vibrio cholerae O-specific polysaccharide that inhibit pathogen motility

This study shows that antibodies against Vibrio cholerae O-specific polysaccharide inhibit bacterial motility and provide protection against cholera in a murine model.

Predicting Vibrio cholerae infection and disease severity using metagenomics in a prospective cohort study

This study uses metagenomic sequencing to predict cholera infection and disease severity in a cohort, identifying protective bacterial species and genes.

Oral immunization with a probiotic cholera vaccine induces broad protective immunity against Vibrio cholerae colonization and disease in mice

This study shows that the live-attenuated cholera vaccine HaitiV provides protection against V. cholerae in mice and their offspring through immunological mechanisms, not vaccine transmission.

Cognate T and B cell interaction and association of Follicular helper T cells with B cell responses in Vibrio cholerae O1 infected Bangladeshi adults

This study investigates the role of follicular helper T (Tfh) cells in B cell responses during Vibrio cholerae O1 infection, finding that Tfh cells expressing CD40L are associated with memory B cell responses and antibody class switching.

Vibrio cholerae genomic diversity within and between patients

This study examines V. cholerae genomic diversity within and between patients, finding limited point mutations but higher gene content variation, including phage and plasmid exchanges, which may impact disease outcomes.