G. Alter

Immune correlates of early clearance of Mycobacterium tuberculosis among tuberculosis household contacts in Indonesia

The paper investigates immune correlates of early Mtb clearance in TB household contacts, finding that BCG vaccination is linked to enhanced innate immune responses rather than adaptive immunity.

Humoral correlates of protection against Mycobacterium tuberculosis following intravenous Bacille Calmette-Guerin vaccination in rhesus macaques

This study identifies humoral immune responses as correlates of protection against Mtb following IV BCG vaccination in rhesus macaques.

Shigella O-specific polysaccharide functional IgA responses mediate protection against shigella infection in an endemic high-burden setting

This study identifies OSP-specific functional IgA responses as protective against shigella infection in high-burden settings by enhancing neutrophil and monocyte activation.

A monkeypox mRNA-lipid nanoparticle vaccine targeting virus binding, entry, and transmission drives protection against lethal orthopoxviral challenge

This paper develops an mRNA-lipid nanoparticle vaccine targeting four conserved MPXV surface proteins, showing superior protection against VACV compared to MVA.

Fc mediated pan-sarbecovirus protection after alphavirus vector vaccination

This study shows that non-neutralizing antibodies targeting FcR4 and spike S2 provide cross-protection against sarbecoviruses after alphavirus vector vaccination.

Fc-gamma receptor-dependent antibody effector functions are required for vaccine protection against infection by antigenic variants of SARS-CoV-2

This study shows that Fc-gamma receptor-dependent antibody effector functions are necessary for vaccine protection against antigenic variants of SARS-CoV-2, including Omicron.

Discrepancy between Mtb-specific IFN-γ and IgG responses in HIV-positive people with low CD4 counts.

This study compares Mtb-specific IFN-γ and IgG responses in HIV-positive and HIV-negative individuals, finding higher IgG levels and lower QFT positivity in HIV-positive people with low CD4 counts.

Longitudinal characterization of circulating neutrophils uncovers distinct phenotypes associated with disease severity in hospitalized COVID-19 patients

This study identifies distinct neutrophil phenotypes linked to disease severity in hospitalized COVID-19 patients using longitudinal data and multi-omics analyses.

Waning and boosting of functional humoral immunity to SARS-CoV-2

This study compares the waning and boosting of functional humoral immunity induced by CoronaVac and BNT162b2 vaccines, showing differences in kinetics and boosting efficacy.

Anamnestic Humoral Correlates of Immunity Across SARS-CoV-2 Variants of Concern

The paper identifies conserved S2-domain antibody responses in anamnestic immunity across SARS-CoV-2 variants, suggesting their role in viral clearance and vaccine design.

Hybrid immunity shifts the Fc-effector quality of SARS-CoV-2 mRNA vaccine-induced immunity

This study compares the humoral immune response in individuals with and without prior COVID-19 after mRNA vaccination, finding that hybrid immunity enhances Fc-effector quality rather than quantity.

Fc-engineered antibodies leverage neutrophils to drive control of Mycobacterium tuberculosis

This study uses Fc-engineered antibodies to enhance Mtb control by leveraging neutrophils, showing restrictive Fc variants improve neutrophil survival and antimicrobial activity in a human whole blood model.

Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children

The paper identifies neutrophil activation and NET formation in MIS-C linked to SARS-CoV-2 immune complexes, differing from acute pediatric COVID-19.

Subtle immunological differences in mRNA-1273 and BNT162b2 COVID-19 vaccine induced Fc-functional profiles

This study compares the Fc-functional antibody profiles of mRNA-1273 and BNT162b2 vaccines in a cohort of hospital staff, finding differences in epitope-specific responses and effector functions.

Functional and structural modifications of influenza antibodies during pregnancy

This study examines how influenza antibodies change structurally and functionally during pregnancy, showing reduced inflammation and increased antibody retention.

Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19

The paper profiles early humoral immune responses in COVID-19 patients, finding that survivors show rapid SARS-CoV-2-specific immunity linked to pre-existing OC43 immunity, while non-survivors have delayed and blunted responses.

An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

This study shows that an intranasal vaccine provides durable protection against SARS-CoV-2 variants in mice, including emerging strains like B.1.351 and B.1.1.28.

Robust IgM responses following vaccination are associated with prevention of Mycobacterium tuberculosis infection in macaques

This study shows that IV BCG vaccination in macaques induces strong IgM responses associated with reduced Mtb bacterial burden and protection.

Sexually dimorphic placental responses to maternal SARS-CoV-2 infection

The paper investigates sex differences in placental responses to maternal SARS-CoV-2 infection, finding sex-specific changes in interferon genes, Fc-receptor expression, and antibody transfer.

Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 in nonhuman primates following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination

This study shows that NVX-CoV2373 vaccine induces antibodies with both neutralizing and Fc-effector functions, which together provide maximal protection against SARS-CoV-2 in non-human primates.

Distinct clonal evolution of B-cells in HIV controllers with neutralizing antibody breadth

The paper analyzes B-cell receptor repertoires in HIV controllers to identify clonal evolution and somatic hypermutation associated with neutralizing antibody breadth.

Modified Vaccinia Ankara Based SARS-CoV-2 Vaccine Expressing Full-Length Spike Induces Strong Neutralizing Antibody Response

This study develops two MVA-based SARS-CoV-2 vaccines, MVA/S and MVA/S1, and finds that MVA/S induces stronger neutralizing antibodies against SARS-CoV-2 compared to MVA/S1.

Integrated technology platform for accelerated discovery of antiviral antibody therapeutics

This study develops an integrated platform to rapidly discover and validate potent antiviral human monoclonal antibodies against Zika virus.

Antibody against envelope protein from human endogenous retrovirus activates neutrophils in systemic lupus erythematosus

The paper identifies an endogenous retrovirus envelope protein, ERV-K102, elevated in SLE patients, which is activated by SLE IgG to promote neutrophil activation and NET formation.

IgG is differentially and selectively transferred across the placenta in HIV-infected women

This study identifies factors affecting placental IgG transfer efficiency in HIV-infected women, showing that maternal disease progression and Fc region characteristics influence selective transfer of antigen-specific IgG.

Human antibody cocktail deploys multiple functions to confer pan-ebolavirus protection

This paper develops a human antibody cocktail, MBP134, that provides broad protection against multiple ebolaviruses, showing enhanced efficacy in guinea pigs compared to individual antibodies.

Two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates

This paper demonstrates that a two-antibody cocktail (MBP134AF) provides broad therapeutic protection against multiple ebolaviruses in ferrets and nonhuman primates.

Outflanking Immunodominance to Target Subdominant Broadly Neutralizing Epitopes

This study shows that immunodominance in influenza HA can be overcome by targeting the conserved stem through specific immunization strategies.