P. Lenart

Plk1 inhibition delays mitotic entry revealing prophase-specific changes to the phosphoproteome

This study shows that Plk1 inhibition delays mitotic entry, revealing prophase-specific phosphoproteome changes and highlighting Plk1's role in the prophase to prometaphase transition.

Phosphoproteomic identification of Mos-MAPK targets in meiotic cell cycle and asymmetric oocyte divisions

The paper identifies Mos-MAPK targets in starfish oocytes using phosphoproteomics, revealing roles in mRNA polyadenylation and cytoskeletal regulation during meiosis.

Timing of mortality during development alters the evolution of aging

The paper uses mathematical models to show that the timing of survival benefits during development affects evolutionary pressures on aging.

TACSTD2 upregulation is an early reaction to lung infection

The paper shows TACSTD2/Trop2 expression increases in infected lungs, primarily from epithelial cells, suggesting a role in barrier function and regeneration.

Learning Mitigates Genetic Drift

This study shows that learning reduces genetic drift in populations by effectively increasing population size, regardless of reproductive mode or ploidy.

Predation Has Small, Short-Term, and in Certain Conditions Random Effect on the Evolution of Aging

This study uses an agent-based model to show predation has small, short-term, and conditionally random effects on the evolution of aging in prey.

Rupture of nuclear envelope in starfish oocytes proceeds by F-actin-driven segregation of pore-dense and pore-free membranes

This study shows that F-actin, driven by Arp2/3, causes nuclear envelope rupture in starfish oocytes by segregating pore-dense and pore-free membranes.

Rethinking mortality rates in men and women: do men age faster?

The paper compares the pace of aging between men and women using mortality data from 13 countries and finds that men age faster than women.

Evolution favors aging in populations with assortative mating and strong pathogen pressure

This paper presents a mathematical model showing aging can evolve in populations with assortative mating and strong pathogen pressure, outcompeting non-aging individuals in certain scenarios.

F-actin patches nucleated on chromosomes coordinate capture by microtubules in oocyte meiosis

The paper shows F-actin patches coordinate with microtubules to ensure proper chromosome capture during oocyte meiosis, preventing aneuploidy.