Y. Schwab

Plasmodium falciparum impairs Ang-1 secretion by pericytes in a 3D brain microvessel model

This paper shows that Plasmodium falciparum impairs Ang-1 secretion by pericytes in a 3D brain microvessel model, leading to vascular dysfunction that can be partially reversed with Ang-1 or AKB-9778.

Sweet and fatty symbionts: photosynthetic productivity and carbon storage boosted in microalgae within a host

This study shows that symbiotic microalgae enhance photosynthetic production and carbon storage within a host, driven by host energetic demands.

High Throughput Tomography (HiTT) on EMBL Beamline P14 on PETRA III

The paper introduces HiTT, a high-throughput X-ray tomography system for rapid 3D imaging of biological samples, demonstrating its application on various tissues and its utility for population studies.

Life cycle-coupled evolution of mitosis in close relatives of animals

The paper investigates mitotic strategies in Ichthyosporea, showing divergence towards fungal-like closed or animal-like open mitosis, with multinucleated life cycles favoring closed mitosis.

CebraEM: A practical workflow to segmentcellular organelles in volume SEM datasetsusing a transferable CNN-based membraneprediction

CebraEM provides a workflow for segmenting cellular organelles in volume SEM datasets using a transferable CNN-based membrane prediction, achieving state-of-the-art results with minimal post-processing.

Targeted volume Correlative Light and Electron Microscopy of an environmental marine microorganism

The paper demonstrates a method to target and analyze the 3D ultrastructure of a photosynthetic marine microorganism using correlative light and electron microscopy.

Hypometabolism to survive the long polar night in the diatom Fragilariopsis cylindrus

This study shows polar diatoms enter a quiescent state during prolonged darkness, relying on autophagy and stored energy to survive, and rapidly resume photosynthesis when light returns.

Crosshair, semi-automated targeting for electron microscopy with a motorised ultramicrotome

The paper introduces a semi-automated workflow for targeting regions of interest in resin-embedded samples using a motorised ultramicrotome and an open-source Fiji plugin called Crosshair.

MOSPD2 a new endoplasmic reticulum-lipid droplet tether functioning in LD homeostasis

This study identifies MOSPD2 as an ER-lipid droplet tether that regulates LD homeostasis through its CRAL-TRIO domain.

Intracellular development and impact of a eukaryotic parasite on its zombified microalgal host in the marine plankton

The paper investigates how the parasite Amoebophrya alters its microalgal host's cellular structure and metabolism during infection, revealing evolutionary conserved mechanisms and a potential zombifying strategy.

Light and electron microscopy continuum-resolution imaging of 3D cell cultures

The paper presents a multi-scale imaging approach for 3D cell cultures that integrates light and electron microscopy to analyze subcellular structures in organoids.

Sensing their plasma membrane curvature allows migrating cells to circumvent obstacles

The paper identifies a curvature-sensing mechanism in immune-like cells that enables obstacle avoidance through actin and membrane dynamics.

CLEMSite, a software for automated phenotypic screens using light microscopy and FIB-SEM

The paper introduces CLEMSite, a software tool for automated phenotypic screens using light microscopy and FIB-SEM, enabling high-throughput volume acquisition with reduced operator supervision.

Subcellular architecture and metabolic connection in the planktonic photosymbiosis between Collodaria (radiolarians) and their microalgae

This study uses multimodal imaging to analyze subcellular changes and nutrient dynamics in the photosymbiosis between Collodaria and their microalgae, revealing metabolic adaptations and nutrient allocation patterns.

Fluorescence-based 3D targeting of FIB-SEM acquisition of small volumes in large samples

The paper presents a method to precisely target FIB-SEM acquisition of fluorescently labeled cells in large samples using fluorescence preservation and confocal imaging.

Cytoklepty in the plankton: a host strategy to optimize the bioenergetic machinery of endosymbiotic algae

The paper shows that host cells manipulate algal endosymbionts to enhance their bioenergetic machinery, leading to increased carbon uptake and photosynthetic efficiency.

In cell architecture of the nuclear pore complex and snapshots of its turnover

The paper uses structural biology and yeast genetics to study NPC architecture and turnover in yeast cells, revealing new insights into mRNA export and autophagy mechanisms.

In-cell quantitative structural imaging of phytoplankton using 3D electron microscopy

This paper develops a 3D electron microscopy workflow to generate nanometric phytoplankton models and identifies conserved subcellular features related to energy management.

Whole-body integration of gene expression and single-cell morphology

The paper integrates gene expression and single-cell morphology in Platynereis dumerilii to identify spatially coherent cell groups defined by transcription factors.

Transcytosis via the late endocytic pathway as a cell morphogenetic mechanism

The paper demonstrates that endocytosis and late endosome trafficking regulate membrane allocation in Drosophila tracheal terminal cells during tubulogenesis.

Spatial control of nucleoporin assembly by Fragile X-related proteins

This paper shows that FXR proteins and dynein help localize nucleoporins to the nuclear envelope and prevent their cytoplasmic aggregation, which affects nuclear morphology and G1 cell cycle progression.

Rupture of nuclear envelope in starfish oocytes proceeds by F-actin-driven segregation of pore-dense and pore-free membranes

This study shows that F-actin, driven by Arp2/3, causes nuclear envelope rupture in starfish oocytes by segregating pore-dense and pore-free membranes.

Software tools for automated transmission electron microscopy

The paper introduces software tools for automated transmission electron microscopy, demonstrating dose reduction and fully automated data acquisition in various applications.

Studying the fate of tumor extracellular vesicles at high spatio-temporal resolution using the zebrafish embryo

This study tracks tumor extracellular vesicles in zebrafish embryos using fluorescent probes, showing their uptake by endothelial cells and macrophages and their behavior in vivo.

Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells

This study shows that blood flow dynamics influence the arrest, adhesion, and extravasation of circulating tumor cells, with implications for metastasis formation.

Postmitotic Nuclear Pore Assembly Proceeds By Radial Dilation Of Small ER Membrane Openings

The paper shows that postmitotic nuclear pore assembly occurs through dilation of ER membrane openings, forming transport channels rapidly.

Alpha-synuclein fibrils induce autophagy in microglial cells as a consequence of lysosomal damage.

This study shows that alpha-synuclein fibrils cause lysosomal damage and autophagy in microglial cells, leading to mitochondrial dysfunction and cell death.

Dynamics of ASC speck formation during skin inflammatory responses in vivo

The paper uses a live ASC reporter in zebrafish to study speck formation and pyroptosis in skin inflammation.