F. Nedelec

Effects of microtubule length and crowding on active microtubule network organization

This study uses simulations and experiments to show that microtubule length and crowding influence active network organization, leading to different dynamic architectures.

Contractile ring composition dictates kinetics of in silico contractility

The paper measures cytokinetic ring component dynamics in C. elegans and shows that realistic constriction kinetics emerge when incorporating measured composition changes into a 3D agent-based model.

Crosslinker design determines microtubule network organization by opposing motors

This study investigates how different crosslinker designs influence microtubule network organization by opposing motors, revealing that asymmetric crosslinkers can support both contractile and extensile behaviors.

Microtubule rescue at midzone edges promotes overlap stability and prevents spindle collapse during anaphase B

This study shows that microtubule rescue at midzone edges stabilizes spindle overlap during anaphase B, preventing collapse by maintaining midzone length without precise growth speed regulation.

Theory of antiparallel microtubule overlap stabilization by motors and diffusible crosslinkers

The paper develops a theoretical framework for antiparallel microtubule overlap stabilization using motors and diffusible crosslinkers, validated by simulations and applied to experimental results.

Cytoskeleton mechanics determine resting size and activation dynamics of platelets.

This study shows that platelet size is linked to microtubule content and that actin-driven coiling of the marginal band occurs during activation, with larger platelets showing greater coiling propensity.

Polarity sorting drives remodeling of actin-myosin networks

The paper investigates how myosin-driven polarity sorting remodels actin-myosin networks, showing that end-dwelling leads to contraction in quasi-2D networks.

F-actin patches nucleated on chromosomes coordinate capture by microtubules in oocyte meiosis

The paper shows F-actin patches coordinate with microtubules to ensure proper chromosome capture during oocyte meiosis, preventing aneuploidy.

Systematic analysis of the molecular architecture of endocytosis reveals a nanoscale actin nucleation template that drives efficient vesicle formation

The paper uses high-throughput superresolution microscopy to analyze endocytic protein organization in yeast, revealing a WASP nano-template that enhances actin nucleation efficiency during vesicle formation.

Crosslinkers both drive and brake cytoskeletal remodeling and furrowing in cytokinesis

This study shows that both motor and non-motor crosslinkers influence cytokinetic furrowing speed, promoting contraction at low levels but braking at higher levels.

A Theory That Predicts Behaviors Of Disordered Cytoskeletal Networks

The paper develops a theory to predict the contractile, expansile, or neutral behavior of isotropic cytoskeletal networks based on filament and connector properties.

Mechanism of Nuclear Movements in a Multinucleated Cell

The paper models nuclear movement in multinucleated fungal hyphae using 3D simulations, showing how microtubules and dynein motors drive oscillatory motion and prevent nuclear clustering.

Balance of microtubule stiffness and cortical tension determines the size of blood cells with marginal band across species

The paper models how the size of blood cells with marginal bands is determined by the balance between microtubule stiffness and cortical tension, verified across 25 species.