P. Maire

Wnt/β-catenin signaling improves oxidative metabolism in skeletal muscle of obese ob/ob mice

This study shows that activating Wnt/β-catenin signaling in skeletal muscle of obese mice improves oxidative metabolism and reduces hyperglycemia.

WhACC: Whisker Automatic Contact Classifier with Expert Human-Level Performance

WhACC is a tool that automatically classifies whisker contacts in rodent videos with human-level accuracy, significantly reducing manual curation time.

A fast Myh super enhancer dictates adult muscle fiber phenotype through competitive interactions with the fast Myh genes

Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle

This study shows that AMPKγ3 is essential for AICAR-induced glucose clearance and uptake in glycolytic muscle but not for ADaM drug-induced effects or adipose thermogenesis.

RhoA within myofibers controls satellite cell microenvironment to allow hypertrophic growth

This study shows RhoA in myofibers promotes hypertrophy by regulating satellite cell fusion through ECM remodeling and macrophage recruitment without affecting protein synthesis.

Single-nucleus RNA-seq and FISH reveal coordinated transcriptional activity in mammalian myofibers

The paper uses snRNA-seq and FISH to show that myonuclei within mammalian myofibers are coordinately expressed, primarily expressing one Myh isoform and showing synchronization early in development.

GREM1 is epigenetically reprogrammed in muscle cells after exercise training and controls myogenesis and metabolism

This study identifies an epigenetic reprogramming of GREM1 in muscle cells after exercise training, which enhances myogenesis and metabolism through the AMPK pathway.