P. Mattjus

Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species (ROS) in human hepatoma cells, which is alleviated by 2-bromopalmitate

This study shows that loss of Nrf1, not Nrf2, causes lipid and ROS accumulation in hepatoma cells, which can be reduced by 2-bromopalmitate.

Ether lipid and sphingolipid expression patterns are G-protein coupled estrogen receptor 1-dependently altered in breast cancer cells

The paper identifies co-expression patterns of lipid classes in breast cancer cells, showing that ether lipids and sphingolipids are upregulated in G-protein coupled estrogen receptor 1-positive cells.

Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor

This study identifies topovectorial mechanisms that control Nrf1 proteolytic processing to generate mature CNC-bZIP transcription factor isoforms through ER-associated degradation.