Author

R. Deng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2 Immunology· 2 Bioinformatics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Organism:mouse· 3 Assay:proteomics· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

Y. Zhang· 3 shared H. Zhu· 2 shared J. Wang· 2 shared L. Wang· 2 shared M. Wang· 2 shared S. Hu· 2 shared S. Tang· 2 shared X. Li· 2 shared

Activity by Year

2021-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCell Biology

Y. Zhang

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

THiRST: Computer Vision Empowered Three-dimensional High-Resolution Spatial Transcriptomics Analytics

J. Zhu, Y. Wang, Z. Lu, C. Qu, Y. Zhu, Y. Yang, S. Zhao, H. Yang, Yuankai Huo, R. Deng

THiRST reconstructs 3D spatial transcriptomic data from serial 2D sections, improving cross-section consistency and enabling 3D gene expression analysis.

bioRxiv · Nov 9, 2026 · PreprintBioinformatics

Cytoophidia influence cell cycle and size in Schizosaccharomyces pombe

R. Deng, Y.-L. Li, J.-L. Liu

This study shows that cytoophidia of CTPS regulate cell cycle and size in S. pombe by affecting G2/M transition and cell growth genes.

bioRxiv · Oct 15, 2023 · PreprintCell Biology

Stanniocalcin 2 (STC2) is a potent biomarker of hepatocellular carcinoma with its expression being augmented in Nrf1α-deficient cells, but diminished in Nrf2-deficient cells

Q. Bu, Y. Deng, Q. Wang, R. Deng, S. Hu, Z. Pei, Y. Zhang

The paper identifies STC2 as a biomarker for hepatocellular carcinoma, showing its expression is increased in Nrf1α-deficient cells and decreased in Nrf2-deficient cells, with STC2 promoting tumor growth.

bioRxiv · May 15, 2023 · PreprintCell Biology

Clostridium butyricum and Clostridium tyrobutyricum: angle or devil for Necrotizing enterocolitis?

Z. H. Wei, R. Tao, G. F. Zong, Y. H. Pan, H. X. Li, P. Chen, R. Deng, W. Chen, A. Wang, S. S. Xia, W. B. Tang, Y. Lu

This study compares the effects of Clostridium butyricum and Clostridium tyrobutyricum on Necrotizing enterocolitis in mice, finding that C. tyrobutyricum alleviates inflammation and improves intestinal barrier integrity, while C. butyricum worsens these conditions.

bioRxiv · Apr 10, 2023 · PreprintMicrobiology

SUMOylation of PTEN promotes DNA end resection through directly dephosphorylating 53BP1 in homologous recombination repair

J. He, Y. Guo, R. Deng, L. Li, C. Huang, R. Chen, Y. Wang, J. Huang, J. Cheng, G.-Q. Chen, J. Zheng, X. Zhao, J. Yu

This study shows SUMOylation of PTEN enhances HR repair by dephosphorylating 53BP1, promoting DNA end resection and inhibiting NHEJ.

bioRxiv · Feb 6, 2023 · PreprintCell Biology

Regulation of protein translation by TRIM21

H. Li, S. Liu, Q. Feng, R. Deng, J. Wang, X. Wang, R. Tian, Y. Xu, S. Chen, Q. Liu, L. Wang, X. Li, M. Wang, Y. Peng, S. Tang, , H. Zhu

This study identifies TRIM21 as a regulator of PKR-mediated protein translation by modulating PP1 ubiquitination and eIF2 dephosphorylation, revealing its role in antiviral defense and potential therapeutic applications.

bioRxiv · Jun 7, 2022 · PreprintImmunology

Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species (ROS) in human hepatoma cells, which is alleviated by 2-bromopalmitate

R. Deng, Z. Zheng, S. Hu, M. Wang, J. Feng, P. Mattjus, Z. Zhang, Y. Zhang

This study shows that loss of Nrf1, not Nrf2, causes lipid and ROS accumulation in hepatoma cells, which can be reduced by 2-bromopalmitate.

bioRxiv · Sep 29, 2021Cancer Biology

Ras guanine nucleotide exchange factor RasGRP1 promotes acute inflammatory response and restricts inflammation-contributed cancer cell growth

C. Wang, X. Li, C. Yu, L. Wang, R. Deng, H. Liu, Z. Chen, Y. Zhang, S. Fan, H. Sun, H. Zhu, J. Wang, S. Tang

This study identifies RasGRP1 as a bifunctional regulator that promotes acute inflammation and inhibits inflammation-associated cancer growth.

bioRxiv · Mar 11, 2021 · PreprintImmunology

Ectopic FVIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma

A. Kapelanski-Lamoureux, Z. Chen, Z.-h. Gao, R. Deng, A. Lazaris, C. Lebeaupin, L. Giles, J. Malhotra, J. Yong, C. Zou, Y. P. de Jong, P. Metrakos, R. W. Herzog, R. J. Kaufman

This study shows that ectopic expression of misfolded BDD-FVIII in hepatocytes promotes hepatocellular carcinoma under high fat diet, independent of viral transduction.

bioRxiv · Jan 19, 2021Cancer Biology