BiophysicsbioRxiv
Structural bases for blockade and activation of BK channels by Ba2+ ions
S. Srivastava, P. Miranda Fernandez, N. de Val…·M. Holmgren
The paper presents Cryo-EM structures of BK channels with Ba2+ ions, showing Ba2+ blocks the channel by occupying the selectivity filter and also binds to Ca2+ sites, with intermediate configurations observed.
DOI 10.3389/fmolb.2024.1454273