M. Holmgren

ATP1A1-linked diseases require a malfunctioning protein product from one allele

The paper investigates whether haploinsufficiency from protein-null ATP1A1 variants causes disease, finding that Atp1a1+/- mice are phenotypically normal and a human with a null variant shows no disease features.

Structural bases for blockade and activation of BK channels by Ba2+ ions

The paper presents Cryo-EM structures of BK channels with Ba2+ ions, showing Ba2+ blocks the channel by occupying the selectivity filter and also binds to Ca2+ sites, with intermediate configurations observed.

Analysis of SARS-CoV-2 ORF3a structure reveals chloride binding sites

The paper analyzes the structure of SARS-CoV-2 ORF3a, identifying chloride binding sites and their dynamic behavior in a simulated tetramer.

The BK channel gating ring is strongly coupled to the voltage sensor

This study shows that the BK channel's gating ring is tightly coupled to the voltage sensor, with conformational changes in the RCK1 domain responding to voltage shifts.