New tools for evaluating protein tyrosine sulphation: Tyrosyl Protein Sulphotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors
P. Eyers, D. Byrne, P. Ngamlert, Y. Li, K. Ramakrishnan, C. Eyers, C. Wells, D. Drewry, W. Zuercher, N. Berry, D. Fernig
The paper develops a non-radioactive assay to quantify tyrosine sulphation by TPST1 and TPST2 and identifies RAF kinase inhibitors as potential TPST inhibitors.
bioRxiv · Apr 6, 2018Biochemistry