Author

K. Ramakrishnan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. Eyers· 2 shared C. Wells· 2 shared D. Drewry· 2 shared D. Fernig· 2 shared D. Jones· 2 shared D. P. Byrne· 2 shared N. Berry· 2 shared P. A. Eyers· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

C. Eyers

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Optimising CNT-FET Biosensor Design: Predictive Modelling of Biomolecular Electrostatic Gating and its Application to Beta-Lactamase Detection

R. Gwyther, S. Cote, C.-S. Lee, K. Ramakrishnan, M. Palma, D. Jones

This study models protein electrostatic interactions with CNT-FETs and demonstrates detection of beta-lactamases using BLIP2 receptors.

bioRxiv · Jul 31, 2023 · PreprintBioengineering

N-linked glycosylation increases horse radish peroxidase rigidity leading to enhanced activity and stability.

K. Ramakrishnan, R. Johnson, S. Winter, H. Worthy, C. Thomas, D. Humer, O. Spadiut, S. Hindson, S. A. Wells, A. Barratt, G. Menzies, C. R. Pudney, D. Jones

This study shows glycosylation increases the rigidity of horseradish peroxidase, enhancing its activity and stability through structural changes.

bioRxiv · Sep 23, 2022 · PreprintBiochemistry

Evolutionary and cellular analysis of the dark pseudokinase PSKH2

D. P. Byrne, S. Shrestha, L. A. Daly, V. Marensi, K. Ramakrishnan, C. E. Eyers, N. Kannan, P. A. Eyers

This study investigates the evolutionary and cellular roles of the pseudokinase PSKH2, confirming its catalytic inactivity and identifying its mitochondrial localization and chaperone-dependent regulation.

bioRxiv · Sep 10, 2022Biochemistry

CTP regulates membrane-binding activity of the nucleoid occlusion protein Noc

A. S. B. Jalal, N. T. Tran, L. J. Wu, K. Ramakrishnan, M. Rejzek, G. Gobbato, C. E. M. Stevenson, D. M. Lawson, J. Errington, T. B. K. Le

This study shows that CTP regulates the membrane-binding activity of the nucleoid occlusion protein Noc in Bacillus subtilis by controlling its ability to form nucleoprotein complexes.

bioRxiv · Feb 11, 2021Microbiology

New tools for carbohydrate sulphation analysis: Heparan Sulphate 2-O-sulphotranserase (HS2ST) is a target for small molecule protein kinase inhibitors

D. P. Byrne, Y. Li, K. Ramakrishnan, I. Barsukov, E. Yates, C. Eyers, D. Papy-Garcia, S. Chantepie, V. Pagadala, J. Liu, C. Wells, D. Drewry, W. Zuercher, N. Berry, D. Fernig, P. A. Eyers

This paper introduces a new non-radioactive assay for HS2ST activity using a synthetic fluorescent substrate and identifies protein kinase inhibitors that inhibit HS2ST-catalyzed sulphation.

bioRxiv · Apr 6, 2018Biochemistry

New tools for evaluating protein tyrosine sulphation: Tyrosyl Protein Sulphotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

P. Eyers, D. Byrne, P. Ngamlert, Y. Li, K. Ramakrishnan, C. Eyers, C. Wells, D. Drewry, W. Zuercher, N. Berry, D. Fernig

The paper develops a non-radioactive assay to quantify tyrosine sulphation by TPST1 and TPST2 and identifies RAF kinase inhibitors as potential TPST inhibitors.

bioRxiv · Apr 6, 2018Biochemistry