W. Zuercher

This paper identifies and characterizes SGC-CLK-1, a potent inhibitor of CLK1, CLK2, and CLK4, showing its selectivity and effects on SR protein phosphorylation and localization.

The paper identifies nematode-specific kinase targets and small molecule scaffolds for developing novel anthelmintics by screening vertebrate kinase inhibitors in C. elegans.

This paper reviews CAMKK2's role in biology and disease, identifies starting points for inhibitor development using literature and databases, and highlights potential for selective inhibitors in oncology, metabolism, and inflammation.

The paper introduces the Kinase Chemogenomic Set (KCGS), a curated collection of 187 selective kinase inhibitors covering 215 human kinases, for use in cell-based screens.

The paper designs and evaluates novel 4-anilinoquinolines and quinazolines as EGFR inhibitors, identifying a potent compound for lung cancer and chordoma treatment.

The paper demonstrates using kinase mini-panels and kinome-wide panels to develop a selective quinoline inhibitor for cyclin G associated kinase (GAK).

This paper introduces a new non-radioactive assay for HS2ST activity using a synthetic fluorescent substrate and identifies protein kinase inhibitors that inhibit HS2ST-catalyzed sulphation.

The paper develops a non-radioactive assay to quantify tyrosine sulphation by TPST1 and TPST2 and identifies RAF kinase inhibitors as potential TPST inhibitors.