C. Wells

Australian researchers' perceptions and experiences with stem cell registration.

This study examines Australian researchers' perceptions of stem cell registration, finding that registration is seen as a publication hurdle and often incomplete, undermining registry goals.

Targeted Sequencing of Pancreatic Ductal Adenocarcinoma Tissue

The paper uses targeted next-generation sequencing to identify mutations in the PAK-PI3K pathway in pancreatic ductal adenocarcinoma tissue, finding five recurrent PAK4 mutations.

A TYPE 2 INNATE LYMPHOID CELL-INTERLEUKIN 9 CIRCUIT INDUCES PANETH CELL METAPLASIA AND SMALL INTESTINAL REMODELING

This study identifies an ILC2/IL-9 immune circuit triggered by extra-intestinal disease that induces Paneth cell metaplasia and small intestinal remodeling in a murine model of CML.

The Human Dendritic Cell Atlas: An integrated transcriptional tool to study human dendritic cell biology

The paper constructs a human dendritic cell (DC) transcriptional atlas by integrating 14 studies, revealing tissue-specific DC subset markers and highlighting gaps between in vitro and in vivo DC models.

Dynamic phase separation of the androgen receptor and its coactivators to regulate gene expression.

This study shows that androgen receptor (AR) and its co-activator MED1 form dynamic, AR-rich condensates at superenhancers in prostate cancer, which are crucial for oncogenic gene expression.

DLL4 and PDGF-BB regulate migration of human iPSC-derived skeletal myogenic progenitors

This study shows that DLL4 and PDGF-BB enhance migration of hiPSC-derived myogenic progenitors without affecting proliferation, supporting their use in muscle therapies.

PKIS Deep Dive Yields a Chemical Starting Point for Dark Kinases and a Cell Active BRSK2 Inhibitor

The paper investigates GW296115, a PKIS compound, showing it inhibits six dark kinases, including BRSK2, with IC50 values under 100nM and demonstrates cell activity.

New tools for carbohydrate sulphation analysis: Heparan Sulphate 2-O-sulphotranserase (HS2ST) is a target for small molecule protein kinase inhibitors

This paper introduces a new non-radioactive assay for HS2ST activity using a synthetic fluorescent substrate and identifies protein kinase inhibitors that inhibit HS2ST-catalyzed sulphation.

New tools for evaluating protein tyrosine sulphation: Tyrosyl Protein Sulphotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

The paper develops a non-radioactive assay to quantify tyrosine sulphation by TPST1 and TPST2 and identifies RAF kinase inhibitors as potential TPST inhibitors.