Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
F. M. Bashore, S. M. Min, X. Chen, S. Howell, C. H. Rinderle, G. Morel, J. A. Silvaroli, C. I. Wells, B. A. Bunnell, D. Drewry, N. S. Pabla, S. K. Ultanir, A. N. Bullock, A. D. Axtman
The paper identifies and characterizes a chemical probe for CDKL2, demonstrating its selectivity and biological impact in neurons and cancer cells.
bioRxiv · May 12, 2024Cell Biology
H. W. Ong, Y. Liang, W. Richardson, E. R. Lowry, C. I. Wells, X. Chen, M. Silvestre, K. Dempster, J. A. Silvaroli, J. L. Smith, H. Wichterle, N. S. Pabla, S. K. Ultanir, A. N. Bullock, D. Drewry, A. D. Axtman
The paper develops a potent and selective CDKL5/GSK3 chemical probe and demonstrates its neuroprotective effects in human motor neurons under ER stress.
bioRxiv · Feb 9, 2023 · PreprintCell Biology
D. Tiek, C. I. Wells, M. Schroder, X. Song, C. A. Ferrer, A. Goenka, R. Iglesia, M. Lu, B. Hu, F. Kwarcinski, P. Sintha, C. de Silva, M. A. Hossain, A. Picado, W. Zuercher, , D. Drewry
This paper identifies and characterizes SGC-CLK-1, a potent inhibitor of CLK1, CLK2, and CLK4, showing its selectivity and effects on SR protein phosphorylation and localization.
bioRxiv · Dec 15, 2022 · PreprintCancer Biology
T. F. dos Reis, P. A. de Castro, R. Bastos, C. F. Pinzan, P. F. Souza, S. Ackloo, M. A. Hossain, D. Drewry, S. Alkhazraji, A. Ibrahim, H. Jo, W. F. deGrado, G. Goldman
This study identifies brilacidin as a compound that enhances the antifungal activity of caspofungin against multiple human pathogenic fungi, including overcoming resistance mechanisms.
bioRxiv · Sep 28, 2022 · PreprintMicrobiology
A. U. Schirmer, L. M. Driver, M. T. Zhao, C. I. Wells, J. E. Pickett, S. N. O'Bryne, B. J. Eduful, X. Yang, L. Howard, S. You, G. R. Devi, J. Digiovanni, S. F. Freedland, J.-T. A. Chi, D. Drewry, E. Macias
This study shows that STK3, typically a tumor suppressor, promotes prostate cancer growth and identifies STK3 inhibitors with therapeutic potential.
bioRxiv · Feb 21, 2021Cancer Biology
D. P. Byrne, Y. Li, K. Ramakrishnan, I. Barsukov, E. Yates, C. Eyers, D. Papy-Garcia, S. Chantepie, V. Pagadala, J. Liu, C. Wells, D. Drewry, W. Zuercher, N. Berry, D. Fernig, P. A. Eyers
This paper introduces a new non-radioactive assay for HS2ST activity using a synthetic fluorescent substrate and identifies protein kinase inhibitors that inhibit HS2ST-catalyzed sulphation.
bioRxiv · Apr 6, 2018Biochemistry
P. Eyers, D. Byrne, P. Ngamlert, Y. Li, K. Ramakrishnan, C. Eyers, C. Wells, D. Drewry, W. Zuercher, N. Berry, D. Fernig
The paper develops a non-radioactive assay to quantify tyrosine sulphation by TPST1 and TPST2 and identifies RAF kinase inhibitors as potential TPST inhibitors.
bioRxiv · Apr 6, 2018Biochemistry