MicrobiologybioRxivPreprint
Enhanced stability of the SARS CoV-2 spike glycoprotein trimer following modification of an alanine cavity in the protein core.
P. Poumbourios, C. Langer, I. Boo…·H. E. Drummer
This paper modifies the SARS-CoV-2 spike protein to enhance thermal stability and neutralizing antibody response against ancestral and Delta variants, but reduced effectiveness against Omicron BA.1.
DOI 10.1101/2022.11.08.515567