P. Sinnis

The paper quantifies sporozoite expulsion from Anopheles mosquitoes infected with P. falciparum gametocytes, finding that infection burden correlates with sporozoite expulsion.

This study shows that atovaquone-resistant Plasmodium falciparum mutants have severe fitness costs in mosquitoes and fail to transmit to mice, reducing the risk of drug resistance spread.

This study identifies and characterizes long non-coding RNAs (lncRNAs) in Plasmodium falciparum, revealing their role in gene regulation, pathogenicity, and sexual differentiation.

This study investigates the role of FcRn in IgG transport into the skin and its impact on antibody-mediated protection against malaria.

This study screens 400 drug-like compounds from the Pathogen Box for activity against Plasmodium falciparum sporozoite motility and identifies five compounds with significant inhibitory effects.

The study identifies the CSP repeat region as a linear spring critical for sporozoite motility and adhesion site formation in malaria parasites.

This study shows that limited Caspase-1 cleavage in hepatocytes reduces pyroptosis and cytokine maturation, impairing malaria control, and that enhancing ASC expression improves immune response.

The paper determines the probability of malaria infection after mosquito bites in a rodent model and finds a non-linear relationship between sporozoite load and infection likelihood.

This paper develops an intravital imaging platform to study P. falciparum sporozoite motility in human skin xenografts and tests interventions against malaria sporozoites.

This study identifies two waves of translational repression in malaria sporozoite maturation using transcriptomic and proteomic data from Plasmodium species.

This paper presents the first proteomic analysis of merosomes in Plasmodium berghei, identifying 1879 proteins and highlighting shared and unique features with blood stage proteomes.