Author

P. Vedula

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Kashina· 5 shared D. W. Dong· 2 shared S. Kurosaka· 2 shared A. House· 1 shared B. A. Bell· 1 shared B. Alexander· 1 shared B. French· 1 shared B. Mactaggart· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersCell Biology

A. Kashina

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5 papers

Recent·Most cited

β-actin is essential for structural integrity and physiological function of the retina

P. Vedula, M. E. Fina, B. A. Bell, S. S. Nikonov, A. Kashina, D. W. Dong

This study shows that β-actin is essential for maintaining normal retinal structure and function, as β-to-γ actin replacement leads to age-related degeneration in mice.

bioRxiv · Mar 27, 2023 · PreprintCell Biology

Protein Posttranslational Signatures Identified in COVID-19 Patient Plasma

P. Vedula, H.-Y. Tang, UPenn COVID Processing Unit, D. Speicher, A. Kashina

This study identifies posttranslational protein signatures in COVID-19 patient plasma through proteomic analysis, revealing changes in phosphorylation, glycosylation, and arginylation.

bioRxiv · Dec 15, 2021Biochemistry

Different translation dynamics of β- and γ-actin regulates cell migration

P. Vedula, S. Kurosaka, B. Mactaggart, Q. Ni, G. A. Papoian, Y. Jiang, D. W. Dong, A. Kashina

The paper shows that differences in translation elongation rates between β- and γ-actin, due to their coding sequences, affect cell migration by altering actin dynamics and focal adhesion function.

eLife · Jun 24, 2021Peer-reviewedCell Biology

A new mechanism of fibronectin fibril assembly revealed by live imaging and super-resolution microscopy.

D. Tomer, C. Arriagada, S. Munshi, B. Alexander, B. French, P. Vedula, V. Caorsi, A. House, M. Guvendiren, A. Kashina, J. Schwarzbauer, S. Astrof

This study reveals that Fn1 fibrils are composed of nanodomains rather than continuous fibers, using live imaging and SMLM to challenge the traditional view.

bioRxiv · Sep 9, 2020Cell Biology

Diverse functions of closely homologous actin isoforms are defined by their nucleotide, rather than their amino acid sequence.

P. Vedula, S. Kurosaka, N. Leu, Y. Wolf, S. Shabalina, J. Wang, S. Sterling, D. Dong, A. Kashina

The paper shows that the functional distinction between β- and γ-actin is determined by their gene sequence, not their protein sequence, through genome editing in mice.

bioRxiv · Dec 1, 2017Cell Biology