A. Kashina

Prospective Fecal Microbiomics Biomarkers for Chronic Wasting Disease

This study identifies fecal microbiome and metabolomics biomarkers that can differentiate CWD-positive from CWD-negative deer with 70% accuracy.

β-actin is essential for structural integrity and physiological function of the retina

This study shows that β-actin is essential for maintaining normal retinal structure and function, as β-to-γ actin replacement leads to age-related degeneration in mice.

Functional interplay between arginyl-tRNA synthetases and arginyltransferase

The paper investigates the functional relationship between arginyltransferase ATE1, arginyl-tRNA synthetases (RARS), and translation, finding that arginylation levels depend on cellular physiology and RARS displacement affects ATE1 activity.

Protein Posttranslational Signatures Identified in COVID-19 Patient Plasma

This study identifies posttranslational protein signatures in COVID-19 patient plasma through proteomic analysis, revealing changes in phosphorylation, glycosylation, and arginylation.

Differential N-terminal processing of beta and gamma actin in vivo

The paper identifies specific N-terminal processing of beta actin in vivo, showing its impact on actin function and cellular behavior.

Different translation dynamics of β- and γ-actin regulates cell migration

The paper shows that differences in translation elongation rates between β- and γ-actin, due to their coding sequences, affect cell migration by altering actin dynamics and focal adhesion function.

A new mechanism of fibronectin fibril assembly revealed by live imaging and super-resolution microscopy.

This study reveals that Fn1 fibrils are composed of nanodomains rather than continuous fibers, using live imaging and SMLM to challenge the traditional view.

Diverse functions of closely homologous actin isoforms are defined by their nucleotide, rather than their amino acid sequence.

The paper shows that the functional distinction between β- and γ-actin is determined by their gene sequence, not their protein sequence, through genome editing in mice.