Author

P. Watchmaker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Yamamichi· 3 shared H. Okada· 3 shared S. Lakshmanachetty· 3 shared T. Nejo· 3 shared C. Hong· 2 shared D. W. Kwok· 2 shared H. Ogino· 2 shared J. F. Costello· 2 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. Yamamichi

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Author profile →

3 papers

Recent·Most cited

Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma

T. Nejo, L. Wang, K. K. Leung, A. Wang, S. Lakshmanachetty, M. Gallus, D. W. Kwok, C. Hong, L. H. Chen, D. A. Carrera, M. Y. Zhang, N. O. Stevers, G. C. Maldonado, A. Yamamichi, P. Watchmaker, , H. Okada

The paper identifies tumor-specific alternative splicing events in glioma that could generate cell-surface antigens but finds significant spatiotemporal heterogeneity and lack of proteomic evidence.

bioRxiv · Oct 26, 2023Cancer Biology

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens

D. W. Kwok, N. O. Stevers, T. Nejo, L. H. Chen, I. Etxeberria, J. Jung, K. Okada, M. Colton Cove, S. Lakshmanachetty, M. Gallus, A. Barpanda, C. Hong, G. K. L. Chan, S. H. Wu, E. Ramos, , H. Okada

The paper identifies tumor-wide splicing aberrations that generate public neoantigens, enabling T-cell-based immunotherapies targeting intratumoral heterogeneity.

bioRxiv · Oct 19, 2023 · PreprintCancer Biology

Glioma-neuronal circuit remodeling induces regional immunosuppression

T. Nejo, S. Krishna, C. Jimenez, A. Yamamichi, J. S. Young, S. Lakshmanachetty, T. Chen, S. S. S. Phyu, H. Ogino, P. Watchmaker, D. Diebold, A. Choudhury, A. G. S. Daniel, D. R. Raleigh, S. L. Hervey-Jumper, H. Okada

This study shows that glioma-induced neuronal circuit remodeling creates regional immunosuppression in glioblastomas by altering tumor-associated macrophages and T-cell infiltration.

bioRxiv · Aug 4, 2023Cancer Biology