S. Krishna

Efficacy of functional connectome fingerprinting using tangent-space brain networks

This paper compares tangent space projections to traditional methods for functional connectome distance calculation, finding tangent space outperforms and requires less data for subject identification.

Targeting Metabolic Dependencies in Acute Myeloid Leukemia: A Dual Strategy using Arsenic Trioxide and Artesunate.

This study investigates the combination of artesunate and arsenic trioxide to treat AML with reduced off-target effects on normal hematopoietic stem cells.

Novel 4,400-year-old ancestral component in a tribe speaking a Dravidian language

This study identifies a fourth ancestral component in Dravidian-speaking tribes, suggesting a Proto-Dravidian ancestry originating around 4,400 years ago, distinct from other known sources.

Coordinated Immune Cell Networks in the Bone Marrow Microenvironment Define the Graft versus Leukemia Response with Adoptive Cellular Therapy

The paper analyzes single-cell data from bone marrow samples to identify immune cell interactions that predict response to adoptive cellular therapy in myeloid leukemia.

Density dependent survival drives variation in density dependent population growth of an insect pest

The paper investigates how density dependence in survival drives variation in density-dependent population growth in Tribolium castaneum across habitats.

Spatially resolved DNP-assisted NMR illuminates the conformational ensemble of α-synuclein in intact viable cells.

This study uses DNP-assisted NMR to show that α-synuclein adopts helical-rich conformations near the cell periphery in intact cells.

Glioma-neuronal circuit remodeling induces regional immunosuppression

This study shows that glioma-induced neuronal circuit remodeling creates regional immunosuppression in glioblastomas by altering tumor-associated macrophages and T-cell infiltration.

Transgenic Mouse Models Establish a Protective Role of Type 1 IFN Response in SARS-CoV-2 infection-related Immunopathology

This study uses transgenic mouse models to show that a heightened type 1 IFN response protects against SARS-CoV-2-induced immunopathology, with Irgm1 as a potential therapeutic target.

Evolutionary dynamics of dengue virus in India

This study analyzes the evolutionary dynamics of dengue virus in India, identifying key genetic changes and immune-driven adaptations in circulating strains.

PERK-ATAD3A interaction protects mitochondrial proteins synthesis during ER stress

The paper identifies ATAD3A as a PERK interactor that modulates PERK-eIF2 signaling during ER stress, allowing selective translation of mitochondrial proteins.

The chemical basis of metabolic interdependence in microbial communities

This study investigates the conditions under which cross-feeding between microbial species is beneficial, finding that certain nonlinearities in metabolic flux distribution allow cross-feeding pairs to outperform autonomous networks.

Ordering and topological defects in social wasps' nests

The paper analyzes the structural order and defects in social wasp nests, finding short-range hexagonal order and specific topological defects.

Selective inhibition of PfATP6 by artemisinins and identification of new classes of inhibitors after expression in yeast

The paper develops a yeast-based screening tool to identify PfATP6 inhibitors, confirming artemisinins target PfATP6 and discovering new inhibitor classes.

Emergence of networks of shared restriction-modification systems in phage-bacteria ecosystems

The paper analyzes RM system sharing in bacterial strains and models phage-bacteria dynamics to identify non-random network structures and two bacterial strategies.

Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of the matricellular protein Mindin

This study identifies Snail's role in maintaining stem/progenitor state in skin epithelial cells and carcinomas via Mindin-mediated autocrine signaling.

Glioblastoma remodeling of neural circuits in the human brain decreases survival

This study shows glioblastomas alter neural circuits in the human brain, reducing survival and impairing cognition through synaptogenic interactions.

Arsenic trioxide resistance in acute promyelocytic leukemia: More to it than PML mutations

This study identifies metabolic rewiring as a mechanism of arsenic trioxide resistance in APL and shows that combining ATO with mitocans can overcome resistance.

Defense versus growth in a hostile world - Lessons from phage and bacteria

The paper models bacterial-phage interactions showing that diversity is determined by a trade-off between growth rate and defense mechanisms, not just growth rate alone.

Metabolite plasticity drives carbon-nitrogen resource budgeting to enable division of labor in a clonal community

The paper shows that aspartate's metabolic plasticity enables carbon-nitrogen resource budgeting, leading to division of labor in yeast colonies.

Asymmetric chromosome segregation and cell division in DNA damage-induced bacterial filaments

This study shows that DNA damage in E. coli leads to filamentation, which is resolved by asymmetric division producing wild-type sized daughter cells.

Metabolic constraints drive self-organization of specialized cell groups

The paper shows that metabolic constraints drive the self-organization of specialized cell groups in a clonal yeast colony under low glucose conditions.

Multifunctional CRISPR/Cas9 with engineered immunosilenced human T cell epitopes

This study shows that Cas9 can be modified to reduce immunogenicity while maintaining its function.

A Suv39H1-low chromatin state drives migratory cell populations in cervical cancers

The paper identifies a Suv39H1-low chromatin state as a driver of migratory cell populations in cervical cancers, linking it to migration, CD66 expression, and poor patient survival.

Complete assembly of a dengue virus type 3 genome from a recent genotype III clade by metagenomic sequencing of serum

This study assembles a complete dengue virus type 3 genome from serum using metagenomic sequencing and identifies co-circulating Japanese encephalitis virus sequences in febrile patients.

Evidence of sinks and sources in the PLC activated PIP2 cycle

The paper uses mathematical modeling to show that the PIP2 cycle must include at least one source and one sink to explain observed metabolic changes.

Daam2 Driven Degradation Of VHL Promotes Gliomagenesis

The paper identifies Daam2 as a factor promoting glioma formation by suppressing VHL expression through ubiquitination and degradation.

Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration

The paper identifies GEFs regulating collective cell migration by screening human bronchial epithelial cells, showing RHOA GEFs influence intercellular communication and motility.