Cell BiologybioRxivPreprint
Cytosolic retention of the mitochondrial protease HtrA2 during mitochondrial protein import stress (MPIS) triggers the DELE1-HRI pathway
P. Y. Bi, S. A. Killackey, L. Schweizer…·S. E. Girardin
This study identifies mitochondrial protein import stress (MPIS) as the trigger for the DELE1-HRI pathway and shows HtrA2 mediates DELE1 cleavage into distinct forms under stress.
DOI 10.1101/2023.02.26.530105